With prostate cancer deaths overtaking that of breast cancer, it is important to know the side effects of finasteride. Adverse effects of 5-reductase inhibitors: What do we know, don't know, and need to know? What's the best treatment to use to try to get my partner pregnant? Incredible! Of course there are some people with severe pfs but even then just wait is shit advice. Accessibility Advertising revenue supports our not-for-profit mission. Post-finasteride syndrome: a surmountable challenge for clinicians. Its like they want to hide possible solutions. Better to learn the cause of PFS and create a cure based on that. Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. Its easy to point to a little blue pill you took 10 years ago than to look for other causes. Mod also deleted my second post where I said he indeed has affiliate links to herbs but doesnt even believe that will be enough for pfs patients, the real cure is proviron, of course he doesnt have any affliate links to those products. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats. doi: 10.1016/j.urology.2018.06.022. Fertility and Sterility. eCollection 2021 Oct. See this image and copyright information in PMC. I did the first day 300 mg clomid, then 100mg for the first two weeks, 50mg for the third week, and none for the forth week. moreplatesmoredates.com. " Finasteride blocks the metabolism of testosterone. reddit Recovered from Post Finasteride Syndrome! : r/tressless Thats probably the worst part if you only read that forum youre pretty much going to feel hopeless. Adverse effects of common medications on male fertility. If medication doesn't allow you to ejaculate semen, you will likely need infertility procedures known as assisted reproductive technology to get your partner pregnant. I just decided to get back on gear after a year off + dutasteride during that time. Ive read theres on guy there who recoverd recently from HCG, very interesting. What medications or herbal remedies do you take? Ive been doing this for over 2 years and have ZERO sexual side effects from the drug. This is a condition characterized by an enlarged prostate. That fog, that mental barrier that kept me feeling a distance from myself had totally lifted. For details, see text. Finasteride Side Effects After Stopping: PFS & What Are They? I'm not going to go into the entire history of what post finasteride syndrome is, and I assume many of you looking into buying Tribulus know exactly what it is. I'll never be without this stuff again. Do you have cloudy urine after an orgasm? .ehsOqYO6dxn_Pf9Dzwu37{margin-top:0;overflow:visible}._2pFdCpgBihIaYh9DSMWBIu{height:24px}._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu{border-radius:2px}._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu:focus,._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu:hover{background-color:var(--newRedditTheme-navIconFaded10);outline:none}._38GxRFSqSC-Z2VLi5Xzkjy{color:var(--newCommunityTheme-actionIcon)}._2DO72U0b_6CUw3msKGrnnT{border-top:none;color:var(--newCommunityTheme-metaText);cursor:pointer;padding:8px 16px 8px 8px;text-transform:none}._2DO72U0b_6CUw3msKGrnnT:hover{background-color:#0079d3;border:none;color:var(--newCommunityTheme-body);fill:var(--newCommunityTheme-body)} Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology. I took intramuscular injections of HCG every 3 a 5 days 1500 to 3000 ui by injections for 1 months only, and after that some Clomid for 10 days 2 pills by day It helped relaunch the natural testorene levels so my libido increased again i am now totally satisfied with my health :slight_smile: https://forum.propeciahelp.com/t/i-believe-i-have-been-cured-by-accident/4054, Yes After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome, All my symptoms have subsided and improved with this method which takes a while but I am fully functional. While we do connect people with vetted, board-certified doctors, we dont provide medical consultations, diagnosis, or advice. All rights reserved. The Baylor study STILL hasnt been released? Proviron saved my life. Therefore, I cut the pills in half (2.5mg) and toss the other half. I haven't had that sort of performance since I was 19 or 20 years old. Of course I said this in a respectable manner Result: post deleted and banned. Depending on the likely cause of your dry orgasms and whether you need evaluation and treatment to help you get your female partner pregnant, you might need to see a urinary and reproductive specialist (urologist). Please visit the wiki for published research, symptoms, and more. Fertility and Sterility. AR: androgen receptor; CSF: cerebrospinal fluid; MRI: magnetic resonance imaging; SRD5A2: 5 alpha reductase type 2 gene. I think it took 6 months before i felt ready to meet a girl again. To be honest, I think for the most part these recoveries werent PFS but rather hormonal imbalances. Many men with retrograde ejaculation are able to get their partners pregnant once they seek treatment. This site complies with the HONcode standard for trustworthy health information: verify here. Understanding all of your options and communicating with your doctor and partner can help. Energy-boosting coffee alternatives: What to know. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y. There was this guy on propecia help called JustQuitDut who was a complete psycho, who thought that taking TRT with estrogen blockers would somehow solve it. doi: 10.1210/jc.2016-2726. If I do achieve an erection it has to be constantly stimulated or it goes away FAST and even thats not a guarantee. I dont really understand why theyre like that. Maybe if theyre lucky in 10 years. My personal experience is that finasteride is an important medication for older guys on TRT that are experiencing BPH. But it is a risk men should discuss with their doctor prior to starting finasteride. Lol, now they banned me, just look at the reason: Dismissive of survey in first few posts; insistently advocated for dangerous and misleading article on PFS. Finasteride is available as a lower-cost generic. 2018;120:143149. All of that changed in three days. At first, I felt absolutely miserable when doing so, it is the worst Ive felt in my life and I was unable to do almost anything but after some weeks it became more tolerable as the receptors lost some of their sensitivity. Look, it's as simple as this. Post-finasteride syndrome - ScienceDirect Yeah the joe_kool guy or whatever his name is had really good luck with TRT, he is honestly the reason I went down this road. Talking with a counselor might help. I did a limited search and did not find other such claims. Archivio Istituzionale della Ricerca Unimi, NCI CPTC Antibody Characterization Program, Agis-Balboa R.C., Guidotti A., Pinna G. 5alpha-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. Mehta A, et al. That is 250IU, not a typo so youll mix your 5000iu HCG with 5CC water and take 1/4 CC intramuscular three times a week using an insulin needle Have you heard about it? Took finasteride for 5 months. -, Baas W.R., Butcher M.J., Lwin A., Holland B., Herberts M., Clemons J., Delfino K., Althof S., Kohler T.S., McVary K.T. If your doctor suspects your dry orgasm is something other than retrograde ejaculation, you might need further tests or a referral to a specialist to find the cause. government site. Eliminate Trigger Foods. I suspect its because my E2 was so low already and that made it feel even lower (single digits if I recall correctly). His article with all the studies hes referencing: Post Finasteride Syndrome can be manually corrected by interpreting blood work and implementing an appropriate lifestyle and/or pharmacological protocol. Public Health. Not orgasm strength and sperm levels have returned, just waiting on my brain to communicate with my penis when its time for sexual intercourse. This after having PFS constantly for 11 years. Palliative care frightens some people: Heres how it helps, Parents don't always realize that their teen is suicidal. This procedure is usually done at the doctor's office. What was the article? Therefore, understand that I can't promise this will work for youbut for me? Very controversial topic in this forum. Yeah, that guy's comment history is really puzzling: When i dared visit PFS forums, the most miserable users there were still in a better state than me. A mod answered and I answered the guy in a normal way, but they deleted my reply and blocked my account. I tried just about everything over 11 years. PFS is a very real, complex and multi-faceted thing - as is the human body. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. Drugs to treat retrograde ejaculation are drugs primarily used to treat other conditions, including: These medications help keep the bladder neck muscle closed during ejaculation. Day 1 I felt no difference. Essentially I took testosterone exogenously And I took hcg afterwards, https://old.reddit.com/r/PSSD/comments/7lfc1e/how_i_fixed_my_pssd/. WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or Hcg I did 3000iu the first day then 250iu every other day for the four weeks. This site needs JavaScript to work properly. To date, the PFS Foundation has identified 104 such professionals who have published scientific findings and/or voiced opinions on causative links between finasteride and PFS. Some of these same doctors and researchers are also members of our Medical Professionals team, counseling PFS patients and their loved ones worldwide. https://camas.github.io/reddit-search/#{%22author%22:%22mrgoodcat1990%22,%22resultSize%22:100,%22query%22:%22pssd%20numbness%22}, ._3K2ydhts9_ES4s9UpcXqBi{display:block;padding:0 16px;width:100%} Finasteride PMC WebNeurogenesis was found to be reversed to normal 35 days after the last finasteride injection in male mice. Brain Res Bull. Their attitude is 100% there is no cure, it wont get better, nothing works, anything that does work doesnt work long term, and thats just how it is. @keyframes ibDwUVR1CAykturOgqOS5{0%{transform:rotate(0deg)}to{transform:rotate(1turn)}}._3LwT7hgGcSjmJ7ng7drAuq{--sizePx:0;font-size:4px;position:relative;text-indent:-9999em;border-radius:50%;border:4px solid var(--newCommunityTheme-bodyTextAlpha20);border-left-color:var(--newCommunityTheme-body);transform:translateZ(0);animation:ibDwUVR1CAykturOgqOS5 1.1s linear infinite}._3LwT7hgGcSjmJ7ng7drAuq,._3LwT7hgGcSjmJ7ng7drAuq:after{width:var(--sizePx);height:var(--sizePx)}._3LwT7hgGcSjmJ7ng7drAuq:after{border-radius:50%}._3LwT7hgGcSjmJ7ng7drAuq._2qr28EeyPvBWAsPKl-KuWN{margin:0 auto} My life is finally back. Jefferys A, et al. | How To Diagnose And Reverse It. Im talking about the physical inability to have erections and sex drive". I also tried testosterone treatment but it had almost no effect regardless of dosage. No energy. Common finasteride side effects include loss of libido, breast enlargement, erectile dysfunction (ED), and lower ejaculatory volume. The symptoms of PFS start to subside within four to eight months after discontinuing the medicine. J. Clin. After stopping, I got ED, extreme fatigue, brain fog, no libido and lethargy. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Book: Mayo Clinic Guide to Fertility and Conception. I am not aware of the use of Human Growth Hormone in the treatment for Post Finasteride Syndrome. 2013 Oct;10(10):2598-603. doi: 10.1111/jsm.12269. Is Post Finasteride Syndrome Real? What is infertility? Get the latest in health news delivered to your inbox! Like I said, almost starting to believe they want people to keep having pfs so they can benefit in some form or another. In: Campbell-Walsh-Wein Urology. The article stated proviron was the best potential cure in his opinion. I need to get back over there and check it out I guess. Inability to concentrate. This report will provide you with the information you need to understand the current controversies, avoid common pitfalls, and work with your doctor to make informed choices about your prostate health. Clinical features reported in patients affected by post-finasteride syndrome. Elsevier; 2021. https://www.clinicalkey.com. At some point you just cant store it all or want to use old drug. The .gov means its official. I am 100% reversed Keep in mind if I miss a dose or stop my protocol Pfs comes back full force. I feel deeply for all my balding brothers out there who are suffering from this poison. Diagnosing and Reversing It", Is Post Finasteride Syndrome Real? Careers. ._1QwShihKKlyRXyQSlqYaWW{height:16px;width:16px;vertical-align:bottom}._2X6EB3ZhEeXCh1eIVA64XM{margin-left:3px}._1jNPl3YUk6zbpLWdjaJT1r{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;display:inline-block;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;padding:0 4px}._1jNPl3YUk6zbpLWdjaJT1r._39BEcWjOlYi1QGcJil6-yl{padding:0}._2hSecp_zkPm_s5ddV2htoj{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;display:inline-block;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;margin-left:0;padding:0 4px}._2hSecp_zkPm_s5ddV2htoj._39BEcWjOlYi1QGcJil6-yl{padding:0}._1wzhGvvafQFOWAyA157okr{font-size:12px;font-weight:500;line-height:16px;border-radius:2px;margin-right:5px;overflow:hidden;text-overflow:ellipsis;vertical-align:text-bottom;white-space:pre;word-break:normal;box-sizing:border-box;line-height:14px;padding:0 4px}._3BPVpMSn5b1vb1yTQuqCRH,._1wzhGvvafQFOWAyA157okr{display:inline-block;height:16px}._3BPVpMSn5b1vb1yTQuqCRH{background-color:var(--newRedditTheme-body);border-radius:50%;margin-left:5px;text-align:center;width:16px}._2cvySYWkqJfynvXFOpNc5L{height:10px;width:10px}.aJrgrewN9C8x1Fusdx4hh{padding:2px 8px}._1wj6zoMi6hRP5YhJ8nXWXE{font-size:14px;padding:7px 12px}._2VqfzH0dZ9dIl3XWNxs42y{border-radius:20px}._2VqfzH0dZ9dIl3XWNxs42y:hover{opacity:.85}._2VqfzH0dZ9dIl3XWNxs42y:active{transform:scale(.95)} Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. I do not think we have an answer to that question one way or the other. AR: androgen receptor; DHP: dihydroprogesterone; DHT: dihydrotestosterone; ER: estrogen receptor beta; PR: progesterone receptor; PROG: progesterone; T: testosterone; THP: tetrahydroprogesterone. Best, Dr. Emer. For what it's worth, here's a couple similar success stories involving numbness, but from PSSD instead of PFS: Testosterone along with initial estrogen management , completely cured my pssd, everything from numbness, to hard on quality , no morning wood, to actually having sexual desires again. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. Pharmaceuticals (Basel). As a 5-alpha reductase inhibitor, finasteride works by inhibiting the effects of the enzyme thats responsible for converting testosterone into dihydrotestosterone (DHT). Endocrinol. Give it 6 months. Do they benefit from people who have pfs so their foundation can continue and ask for more donations? Key takeaways: Finasteride is an FDA-approved medication that treats hair loss in men. Melcangi RC, Caruso D, Abbiati F, Giatti S, Calabrese D, Piazza F, Cavaletti G. J Sex Med.