WebPost-finasteride syndrome (PFS) describes persistent sexual, neurological, physical and mental adverse reactions in patients who have taken finasteride, a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (under the brand name Propecia or generics) or enlarged prostate (Proscar or generics). Ive made a 80% recovery so far and I keep improving however your hypothesis is quite scary. Some research suggests that more than 50 percent of men in will experience some form of hair loss by the time they hit 50 years old. Unlike regular finasteride side effects, post-finasteride syndrome is designed as persistent side effects from finasteride that can continue after the medication is discontinued. It scrambles your hormones, libido and cognition all over the place, right into the gutters, and leaves you feeling like an empty dysfunctional husk. I'm a PFS sufferer that has been doing the HCG protocol for only a week now and seeing/feeling amazing benefits already. Sure I can do that for you. National Library of Medicine An official website of the United States government. I found some recovery stories with these compounds. Do not use for customer service inquires. After 15 years of research i also believe mycotoxins are playing a big role in this, mycotoxins damage the grey matter in your brain which would cause dopamine issues, then a cascade of issues from hpa axis dysfunction, gut issues, hormone issues which wont go away under a complete mycotoxin detox is done. PMC 2016 Mar;4(2):245-50. doi: 10.1111/andr.12147. I am investigating other solutions. Post i been suffering for close to a year from just 3 weeks of usage. Federal government websites often end in .gov or .mil. Finasteride, which is sold as a generic and under the brand name Propecia, is one of the most popular medications on the market for treating and preventing male pattern baldness. In short, being aware that finasteride may cause sexual side effects is associated with a higher risk of actually experiencing these side effects. Although increasing number of men report persistent side effects, the medical community has yet to recognize this syndrome nor are there any specific measures to address this serious and debilitating symptoms. If PFS patients and/or family members encounter resistance to and dismissal of PFS as a real medical condition by their doctor, but their doctor is at least open-minded, we recommend that they ask him/her to carefully review this literature and news, along with our PFS Diagnostic Criteria, Doctors & Researchers Speaking Out, PFS Quilt and Propecia Litigation Library pages. Unauthorized use of these marks is strictly prohibited. According to the National Institutes of Health, scientific research is underway to better understand the effects of 5-alpha reductase inhibitor drugs like finasteride. My hypothesis is that finasteride can cause brain damage which needs to be reversed. It may not display this or other websites correctly. Would you like email updates of new search results? These customers results have not been independently verified. Ive read about him saying this is pro-fat metabolism and Haidut has an article on how hCG is considered a marker for cancer when it is in fact a promotor of cancer in itself because it trigger cell growth. However, there have been no published medical studies that report on the effectiveness of SSRIs to treat PFS. I wish you could share more research about how you chose to do it. A few of the best ways to lower prolactin include: For more a comprehensive guide on lowering prolactin, check out this article: Serotonin is most often high in all mental and physical disorders and there is always a serotonin receptor/s gone rogue. This is the FDA-approved dynamic duo. Are you sensitive to dietary fats and have greasy stool with fat floating on the surface of the water after pitching a loaf? It is a severely underrated and misunderstood drug. So far I tread Clomid and nolvadex cycles but I only had one day where libido returned, rest of time didnt feel anything good or bad when on it. A: Yes. I took a topical of Fin/Minoxidil for less than 3 months and just recently have experience whole body weakness, stiffness, joint pain, brain fog and a lower feeling of well-being/happiness. According to a 2017 study published in PeerJ and titled Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors finasteride or dutasteride, 1.2% of young men (defined as those 16 to 42 years old) who took finasteride for 206 days or longer, and had no prior history of sexual dysfunction, developed persistent erectile dysfunction (PED) that lasted an average of 4.2 years after quitting the drug. Replacing testosterone helps recover the DHT receptors and is the only treatment known. Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis. My hair is back to what it was in my mid twenties.. Free shipping on Rx medication, if prescribed. Additionally, the World Health Organizations VigiBase database of adverse reactions to dutasteride paints an epidemiological profile similar to that of finasteride. 2019 Apr;7(2):277-282. doi: 10.1016/j.sxmr.2018.07.003. Thank you so much for your time. Unlike finasteride, you dont need a doctors prescription to purchase and use this medication. It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. A second factor that may explain the symptoms of post-finasteride syndrome is existing mental illness. You must log in or register to reply here. I havent seen any reports of hcg triggering cell growth. The .gov means its official. This is a difficult question to answer as there is a small minority of PFS patients who have reported anecdotally that they have developed PFS only after quitting finasteride. Other PFS patients anecdotally report PFS symptoms while using finasteride that get worse after quitting the drug. This condition, termed post-finasteride syndrome (PFS) is characterized by sexual side effects (i.e., low libido, erectile dysfunction, decreased arousal and difficulty in Brian fog Hi David, Differential Gene Expression in Post-Finasteride Syndrome Patients A: At the moment, theres no known test for determining whether any finasteride patient will develop PFS. It can and does, although they typically arent common. Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. You are good person for sharing this. Noteworthy is that these two symptoms commonly coexist also in subjects who are not exposed to finasteride. Although the symptoms of post-finasteride syndrome are alarming, its important to keep in mind that they are incredibly rare, even in long-term finasteride users. Oral testosterone: Hows the best way to take it? I just want to make sure i dont make any mistakes. A: Most likely, yes. Still, anyone interested in absolute numbers of reported PFS symptoms should review the World Health Organizations VigiBase database of adverse drug reactions (ADRs), which currently contains more than 18,000 finasteride ADRs. Do you have any digestive issues? However, many men who were treated with a placebo medication also reported the same side effects: 1.3 percent of men who received the placebo reported decreased libido, 0.7 percent of men who received the placebo reported erectile dysfunction, 0.7 percent of men who received the placebo reported ejaculation disorder. I have another friend ready to start and I'm excited for his recovery next. Frequently Asked Questions - The Post-Finasteride I am quite distressed atm and hope this is not permanent and everyone is telling me Im just hypochondriac but I know my sexual function is inhibited for the time being. Q8: I cant find a doctor in my area whos familiar with PFS. Listed there are more than 80 doctors, psychologists and pharmacologists who counsel PFS patients and their family members. What kind of doctor would be willing to help with something like this? Scary just how much of an adverse affect nnEMFs have. Unauthorized use of these marks is strictly prohibited. Finasteride was the first on the market and is currently the most widely used inhibitor. Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body over time. Neuroactive steroid levels are modified in cerebrospinal fluid and I want to try a solution like HCG low dose: The https:// ensures that you are connecting to the Topical progesterone the skin is rich in 5-AR, so applying progesterone to the skin should increase allopregnanolone. Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. You can send me an email at menelite101@gmail.com with your labs (and any addition info you might deem relevant) so I can take a look. It just means that you might have to implement certain strategies and use certain supplements for quite some time before the enzymes normalize. Post-Finasteride Syndrome: What is It? | hims Should I stop taking the drug cold turkey, or gradually taper off it? FOIA Among the men who used the placebo, 5.1 percent also reported experiencing erectile dysfunction. Doses have ranged between 1200mg and 3600mg per day without significant side effects. If so, well reach out to our entire PFS patient population to let you know and to provide you with participation parameters. Alongside thyroid. Like other medications, finasteride went through several large-scale clinical trials before it finally received approval from the FDA. Physical improvements down below as well. The depression of PFS can be very debilitating and finding effective treatments for the depression of PFS can be challenging and require considerable trial and error in consultation with your doctor. - PubMed - NCBI, Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism, Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression, Elevated ESR and hCG levels are strong predictors of impending cancer diagnosis To Extract Knowledge from Matter, Thoughts On 5ar And Post Finasteride Syndrome, Post Finasteride Syndrome And Low Insuline, Post Finasteride Sydrome - Neuropathic Pain, Low-Dose HCG Maintains Intratesticular T In Normal Men With T-Induced Gonadotropin Suppression, DHT And Reversing Androgen-receptor Deficiency, Elevated ESR And HCG Levels Are Strong Predictors Of Impending Cancer Diagnosis, Post Finasteride Sydnrome, And The 5ar1 And 2 Isoenzymes, Post Finasteride/ High Cortisol/ Low Gaba. It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. no libido Prolactin is a bugger when it comes to mood and cognitive function. I can definitely have a look for you and see if I find anything that needs optimization. Alternatively, you can use other treatments, such as those available in our Non-Prescription Hair Loss Kit, to treat male pattern baldness without taking oral finasteride. Post-finasteride syndrome: a surmountable challenge for clinicians. Sexual functioning is returning to some extent. Post-Finasteride Syndrome Foundation v. FDA Co-use is likely to be common by patients, but the effects of co-use are not known. ). I have tried a few of the a above already alone with no improvement however I think a holistic combination may be the answer. Before The same pattern occurred with decreased libido, with 2.6 percent of finasteride users and 2.6 percent of placebo users both reporting this side effect. If youd like to suggest adding one, please email patient manager Philip Roberts at proberts@pfsfoundation.org.). Thanks for reaching out. Vitamin C for erectile dysfunction: the best vitamin for ED? Finasteride is a 5-alpha reductase inhibitor thats used to treat androgenetic alopecia (a clinical term for male pattern baldness) and benign prostatic hyperplasia (non-cancerous growth of the prostate gland). Optimize thyroid. I had no noticeable sides until sexual problems which started 3 weeks ago so I stopped. I wanted to talk about my 2 year battle with Post Finasteride Syndrome (PFS), in hopes of helping anyone who is going through what As for hair loss shampoos, many include ingredients such as ketoconazole and saw palmetto to block DHT at the scalp level. HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. Thanks man, much appreciated. Post Finasteride Syndrome Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. Accessibility We require a human profile pic upon registration on this forum. really have been feeling like an empty husk like described lately, almost like a part of me was ripped out, but maybe one day i can find it again. 2023 Feb 2;12(3):653. doi: 10.3390/plants12030653. Then he/she implied that its probably all in my head. My goal is to get off Trazodone as quickly as possible, any recomendationsto further aid with insomnia ? and transmitted securely. Based on the symptoms and descriptions provided online, post-finasteride syndrome can sound like a severe, untreatable condition. I tried several different options before but Hims combined approach of all four methods by far created the best results., Hims has been the greatest confidence boost, no more bald jokes! WebLarge scale studies have found that after cessation of the product, these side effects are reversed and in many, after long-term use, they can cease. For diagnostic criteria of the condition, see our PFS Diagnostic Criteria page.). I will start Progesterone cream with tongkat ali soon. A: According to the Finasteride Drug Summary in Prescriber's Digital Reference: Saw palmetto may inhibit 5 alpha-reductase, preventing the conversion of testosterone to dihydrotestosterone. Customers were given free product.. https://www.ncbi.nlm.nih.gov/books/NBK513329/, https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia, https://www.pfsfoundation.org/about-pfs-post-finasteride-syndrome/, https://www.pfsfoundation.org/frequently-asked-questions/, https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020788s028lbl.pdf, https://www.karger.com/Article/Fulltext/497362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401955/, https://pubmed.ncbi.nlm.nih.gov/17655657/, https://pubmed.ncbi.nlm.nih.gov/27662439/, https://medlineplus.gov/genetics/condition/androgenetic-alopecia/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540144/, https://www.ncbi.nlm.nih.gov/books/NBK482378/, https://www.scitcentral.com/article/19/60/Randomized-Comparative-Research-Study-of-Topical-and-Oral-Finasteride-with-Minoxidil-for-Male-Pattern-Androgenetic-Alopecia-in-Indian-Patients, https://www.ijord.com/index.php/ijord/article/view/394, https://rarediseases.info.nih.gov/diseases/12407/adverse-events-of-5-alpha-reductase-inhibitors, many vitamins are vital for proper hair growth. After finasteride is discontinued, the body must produce new 5-alpha-reductase molecules to replace the ones that were inactivated by the finasteride. Book Full Body Checkups. Who would have thought trying to enhance the hairline would cause bigger problems! I have blood and hormones test results if u want. It is important to note that many clinical studies suffer from incomplete or inadequate assessment of adverse events and often limited or inaccurate data reporting regarding harm. Unable to load your collection due to an error, Unable to load your delegates due to an error. However, it does raise questions about the theory that finasteride has the potential to cause lasting, long-term, severe side effects. 30 mg/kg doses have been studied in children. A third factor is that a lot of the problems commonly described as symptoms of post-finasteride syndrome are common in middle-aged and older men, particularly men in the age group that is most likely to develop noticeable male pattern baldness. More and more, doctors who do so wind up contacting the foundation directly to inquire further about the condition. Clipboard, Search History, and several other advanced features are temporarily unavailable. Im a newbie here so dont hold me very accountable here. Any idea why that may be? Epub 2018 Oct 6. Some people get results, but often only 1 steroid isnt enough. I think this is anti-peat. Researchers have found low levels of neurosteroids, including allopregnanolone, in the cerebrospinal fluid of post-finasteride syndrome patients. Do you sleep in a tent? Several studies over the past decade, for example, from Dokras,[], Illustration by Marta Pucci. The men that received the placebo reported similar side effects: 3.7 percent of men who received the placebo reported erectile dysfunction, 3.4 percent of men who received the placebo reported decreased libido, 0.8 percent of men who received the placebo reported decreased ejaculatory volume. The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation. Lets say your DHT is low, here are the top 7 supplements you can use to increase it: If you want additional methods on increasing DHT apart from supplements, check out my comprehensive article on boosting DHT: If DHT is normal and you still feel off, mainly anxious, not confidence, shy, nervous, experiencing brain fog, etc., you might be low in allopregnanolone. Full Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Rev Endocr Metab Disord. Post-finasteride syndrome: An emerging clinical problem You can argue with the theoretician but you cant argue with the anecdotal stories of successful recovery. Whats happening to the progesterone if I try HCG? 2012 Nov;9(11):2927-32. doi: 10.1111/j.1743-6109.2012.02846.x. 3 reasons why eating raw bull testicles for boosting testosterone is useless! 2020 Sep;204(3):602. doi: 10.1097/JU.0000000000001168.01. The only problem is that I have an high PROGESTERONE and High colesterol out of higher range both. There are no known scientific reports of PFS patients returning to full health. HCG will increase progesterone or will decrease it? Chiriac G, Cauci S, Mazzon G, Trombetta C. Andrology. Q13: I understand we dont know which is riskier, quitting finasteride or staying on it, but I still want to quit. One key indisputable clinical evidence noted in all reported studies with finasteride and dutasteride was that use of these drugs is associated with development of sexual dysfunction, which may persist in a subset of men, irrespective of age, drug dose or duration of study. In 2013, Swiss pharmaceutical company Polichem SA conducted a study, published in the Journal of the American Academy of Dermatology and titled Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia, which showed that topical finasteride is absorbed and lowers serum DHT levels almost to the same degree as the oral medication. Ruksiriwanich W, Linsaenkart P, Khantham C, Muangsanguan A, Sringarm K, Jantrawut P, Prom-U-Thai C, Jamjod S, Yamuangmorn S, Arjin C, Rachtanapun P, Jantanasakulwong K, Phimolsiripol Y, Barba FJ, Sommano SR, Chutoprapat R, Boonpisuttinant K. Plants (Basel). A: Thats a key question in the PFS riddle. Like in the above trial, men placed in the control group received a non-therapeutic placebo. One of the PFS Foundations chief goals is to achieve universal awareness and acceptance of PFS as a bona fide and serious medical condition. Josh's optimal journal (recovery from Post Finasteride Prostatis One way to treat your hair loss without using finasteride is to use non-prescription treatments for hair loss, such as minoxidil, hair loss shampoo and hair growth vitamins. Here are a few things you can do: Finasteride binds to 5-R type 2 with high affinity and dissociates very slowly with a half-life of 31 days. For example, during the second, third and fourth years of the trial, 5.1 percent of men who used finasteride 5mg reported experiencing erectile dysfunction. Feel free to discuss remedies, research, technologies, hair transplants, living with hair loss, cosmetic concealments, whether to "take the plunge" and shave your head, and how your treatment progress or shaved head or hairstyle looks.